Post by osrb on May 18, 2011 8:54:05 GMT -5
Coffee Consumption and Prostate Cancer Risk and Progression in the Health Professionals Follow-up Study
Kathryn M. Wilson,
Julie L. Kasperzyk,
Jennifer R. Rider,
Stacey Kenfield,
Rob M. van Dam,
Meir J. Stampfer,
Edward Giovannucci and
Lorelei A. Mucci
+ Author Affiliations
Affiliations of authors: Department of Epidemiology (KMW, JLK, SK, MJS, EG, LAM) and Department of Nutrition (RMvD, MJS, EG), Harvard School of Public Health, Boston, MA; Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (KMW, JLK, JRR, SK, MJS, EG, LAM); Department of Urology, Örebro University Hospital, Örebro, Sweden (JRR); Department of Epidemiology and Department of Public Health and Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore (RMvD)
Correspondence to: Kathryn M. Wilson, ScD, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115 (e-mail: kwilson@hsph.harvard.edu).
Received September 1, 2010.
Revision received March 31, 2011.
Accepted April 1, 2011.
Abstract
Background Coffee contains many biologically active compounds, including caffeine and phenolic acids, that have potent antioxidant activity and can affect glucose metabolism and sex hormone levels. Because of these biological activities, coffee may be associated with a reduced risk of prostate cancer.
Methods We conducted a prospective analysis of 47 911 men in the Health Professionals Follow-up Study who reported intake of regular and decaffeinated coffee in 1986 and every 4 years thereafter. From 1986 to 2006, 5035 patients with prostate cancer were identified, including 642 patients with lethal prostate cancers, defined as fatal or metastatic. We used Cox proportional hazards models to assess the association between coffee and prostate cancer, adjusting for potential confounding by smoking, obesity, and other variables. All P values were from two-sided tests.
Coffee Consumption and Prostate Cancer
*************************************
WooHoo another great reason for me to drink my pot (or 2) of coffee a day.
Kathryn M. Wilson,
Julie L. Kasperzyk,
Jennifer R. Rider,
Stacey Kenfield,
Rob M. van Dam,
Meir J. Stampfer,
Edward Giovannucci and
Lorelei A. Mucci
+ Author Affiliations
Affiliations of authors: Department of Epidemiology (KMW, JLK, SK, MJS, EG, LAM) and Department of Nutrition (RMvD, MJS, EG), Harvard School of Public Health, Boston, MA; Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (KMW, JLK, JRR, SK, MJS, EG, LAM); Department of Urology, Örebro University Hospital, Örebro, Sweden (JRR); Department of Epidemiology and Department of Public Health and Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore (RMvD)
Correspondence to: Kathryn M. Wilson, ScD, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115 (e-mail: kwilson@hsph.harvard.edu).
Received September 1, 2010.
Revision received March 31, 2011.
Accepted April 1, 2011.
Abstract
Background Coffee contains many biologically active compounds, including caffeine and phenolic acids, that have potent antioxidant activity and can affect glucose metabolism and sex hormone levels. Because of these biological activities, coffee may be associated with a reduced risk of prostate cancer.
Methods We conducted a prospective analysis of 47 911 men in the Health Professionals Follow-up Study who reported intake of regular and decaffeinated coffee in 1986 and every 4 years thereafter. From 1986 to 2006, 5035 patients with prostate cancer were identified, including 642 patients with lethal prostate cancers, defined as fatal or metastatic. We used Cox proportional hazards models to assess the association between coffee and prostate cancer, adjusting for potential confounding by smoking, obesity, and other variables. All P values were from two-sided tests.
Coffee Consumption and Prostate Cancer
*************************************
WooHoo another great reason for me to drink my pot (or 2) of coffee a day.
